Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated Caucasian multicase families: disease association with the extended haplotype [HLA-B8, SC01, DR17]

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease often clustered in families. We investigated the association between MHC haplotypes and SLE in multicase Caucasian families. Ten consecutive families with 2 or more patients with SLE, in total 27 patients among 66 individuals, wer...

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Bibliographic Details
Published inJournal of rheumatology Vol. 22; no. 10; p. 1852
Main Authors Truedsson, L, Sturfelt, G, Johansen, P, Nived, O, Thuresson, B
Format Journal Article
LanguageEnglish
Published Canada 01.10.1995
Subjects
Adult
Aged
Alleles
Complement C4 - genetics
European Continental Ancestry Group - genetics
Female
Haplotypes
HLA Antigens - analysis
Humans
Lupus Erythematosus, Systemic - ethnology
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Major Histocompatibility Complex
Male
Middle Aged
Pedigree
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Summary:Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease often clustered in families. We investigated the association between MHC haplotypes and SLE in multicase Caucasian families. Ten consecutive families with 2 or more patients with SLE, in total 27 patients among 66 individuals, were studied. MHC haplotypes were determined by typing for HLA-A, B, C, DR, and DQ by serological and DNA methods. Complotypes were determined by protein typing and C4 gene polymorphism by DNA analysis. Fifty-four independent MHC haplotypes were found. Ten of the 31 haplotypes in the patients with SLE were examples of the extended haplotype [HLA-B8,SC01,DR17]. Six of these were found in 2 or more patients with SLE within the same family. All the 14 SLE sib-pairs in the families shared at least one haplotype and in 9 of the sib-pairs the shared haplotype was [HLA-B8,SCO1,DR17]. Three SLE associated haplotypes were [HLA-B7,SC31,DR15]. Four of the 27 patients with SLE were C4A deficient. Two C2 deficient siblings were homozygous for the haplotype [HLA-B18,S042,DR15]. We demonstrate that a very limited number of MHC haplotypes are associated with familial SLE. The haplotype [HLA-B8,SCO1,DR17] was closely related with the disease. There was no evidence suggesting familial SLE constitutes a disease subset. Determination of MHC haplotypes in multicase families is of value for assessment of disease susceptibility.
ISSN:0315-162X