Efficacy and tolerance of a novel topical TRPV-1 channel antagonist in dogs with allergic pododermatitis

• Published in: Veterinary dermatology Vol. 34; no. 6; pp. 514 - 522
• Main Authors: Serra Fabregat, Xavier, de Pablo, Miguel Ángel, Hernán-Pérez, Conchita, Diéguez, Elena, Valero Coppin, Oliver, Genové Corominas, Elsa
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2023
• Subjects: Capsaicin receptors; Dogs; Infections; Pruritus; Quality of life; Skin diseases; Skin lesions; Transient receptor potential proteins; allergies; pruritus; atopy; secondary infection; vanilloid receptors; skin diseases
• ISSN: 0959-4493; 1365-3164
• DOI: 10.1111/vde.13185

Pruritus due to allergic skin disease is one of the most common reasons for dermatological consultations in the veterinary clinic. Treatment is usually multimodal and requires continuous monitoring and reassessment. New therapies are needed to broaden the therapeutic arsenal. The aim of this study was to evaluate the efficacy of a novel transient receptor potential vanilloid 1 (TRPV1) channel antagonist for allergic pododermatitis in dogs. Twenty-four client-owned dogs with allergic pododermatitis. The study was an open, prospective, multi-centre clinical trial with client-owned dogs. All dogs were treated twice daily with a spray containing hydroxymethoxyiodobenzyl glycolamide pelargonate for 28 days. Clinical assessments included pruritus Visual Analog Scale (PVAS), pedal skin lesion score, evaluation of quality of life (QoL), presence of secondary infections and a four-point subjective efficacy assessment by the veterinarian and the dog owner. There was more than 50% improvement in all scores by the conclusion of the study. Secondary infections were reduced (p < 0.001). Both the veterinarians and dog owners evaluated the efficacy of the product positively. The product was well-tolerated. This study demonstrated the tolerability and efficacy of a TRPV1 antagonist on pruritic pododermatitis in 24 dogs.