An Ultrasmall SnFe2O4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

• Published in: Advanced functional materials Vol. 31; no. 5
• Main Authors: Feng, Lili, Liu, Bin, Xie, Rui, Wang, Dongdong, Qian, Cheng, Zhou, Weiqiang, Liu, Jiawei, Jana, Deblin, Yang, Piaoping, Zhao, Yanli
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.01.2021
• Subjects: Antioxidants; Catalase; chemodynamic therapy; Computed tomography; Depletion; Free radicals; Glutathione; Hydrogen peroxide; Hydroxyl radicals; Hypoxia; Magnetic properties; Magnetic resonance imaging; Materials science; nanozyme; Peroxidase; Photodynamic therapy; Photothermal conversion; tin ferrite; tumor microenvironment
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.202006216

The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels of hydrogen peroxide (H2O2) dramatically limits the antitumor efficiency by monotherapy. Herein, a novel TME‐modulated nanozyme employing tin ferrite (SnFe2O4, abbreviated as SFO) is presented for simultaneous photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The as‐fabricated SFO nanozyme demonstrates both catalase‐like and GSH peroxidase‐like activities. In the TME, the activation of H2O2 leads to the generation of hydroxyl radicals (•OH) in situ for CDT and the consumption of GSH to relieve antioxidant capability of the tumors. Meanwhile, the nanozyme can catalyze H2O2 to generate oxygen to meliorate the tumor hypoxia, which is beneficial to achieve better PDT. Furthermore, the SFO nanozyme irradiated with 808 nm laser displays a prominent phototherapeutic effect on account of the enhanced photothermal conversion efficiency (η = 42.3%) and highly toxic free radical production performance. This “all in one” nanozyme integrated with multiple treatment modalities, computed tomography, and magnetic resonance imaging properties, and persistent modulation of TME exhibits excellent tumor theranostic performance. This strategy may provide a new dimension for the design of other TME‐based anticancer strategies. A tumor microenvironment‐modulated tin ferrite nanozyme is presented for computed tomography and magnetic resonance imaging‐guided synergistic therapy against tumors. The nanozyme exhibits both catalase and glutathione peroxidase‐like activities, showing simultaneous photothermal, photodynamic, and chemodynamic therapy when irradiated by 808 nm laser.