Relationship between total thiol status and thrombocytopenia in patients with Crimean-Congo hemorrhagic fever

• Published in: Southeast Asian journal of tropical medicine and public health Vol. 43; no. 6; pp. 1411 - 1418
• Main Authors: Guner, Rahmet, Tasyaran, Mehmet A, Keske, Siran, Hasanoglu, Imran, Kalem, Ayse Kaya, Yapar, Derya, Gulen, Tugba Arslan, Neselioglu, Salim, Isikoglu, Semra, Erel, Ozcan
• Format: Journal Article
• Language: English
• Published: Thailand Central Coordinating Board, SEAMEO-TROPMED Project 01.11.2012
• Subjects: Case-Control Studies; Dithionitrobenzoic Acid; Female; Hemorrhage; Hemorrhagic fever; Hemorrhagic Fever, Crimean - blood; Hemorrhagic Fever, Crimean - complications; Humans; Male; Middle Aged; Oxidants; Oxidants - blood; Platelet Count; Platelets; Public health; ROC Curve; Sulfhydryl Compounds - blood; Thiols; Thrombocytopenia; Thrombocytopenia - blood; Thrombocytopenia - etiology; Turkey; Turkey
• ISSN: 0125-1562

The objective of this study was to investigate the relationship between serum total thiol level and total oxidant status (TOS) and thrombocytopenia among patients with Crimean-Congo hemorrhagic fever (CCHF). Eighty-three subjects and 56 controls were enrolled in the study. Thiol levels were measured with the DTNB method and TOS was measured with the Erel's method among subjects and controls. Thiol levels were lower in subjects than controls and TOS levels were higher in subjects than controls. There was a significant correlation between total thiol levels and platelet counts (r = 0.84, p < 0.0001) among subjects. Further investigations are needed into the link between total thiol level and TOS and the pathogenesis of hemorrhage in CCHF.