SEROPREVALENCE OF CYTOMEGALOVIRUS INFECTION IN PREGNANT WOMEN AND ASSOCIATED ROLE IN OBSTETRIC COMPLICATIONS: A PRELIMINARY STUDY

The objective of this study was to determine the seroprevalence of cytomegalovirus (CMV) infections through antenatal screening data and the association of this virus with obstetric complications. Serum samples from 125 apparently healthy pregnant women sent for antenatal screening from various hosp...

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Published inSoutheast Asian journal of tropical medicine and public health Vol. 42; no. 2; pp. 320 - 322
Main Authors SARASWATHY, T. S, AZ-ULHUSNA, A, NURUL ASSHIKIN, R, SURIANI, S, ZAINAH, S
Format Journal Article
LanguageEnglish
Published Bangkok SEAMO, Regional Tropical Medicine and Public Health Network 01.03.2011
Central Coordinating Board, SEAMEO-TROPMED Project
Subjects
Abortion, Incomplete - virology
Biological and medical sciences
Congenital Abnormalities - virology
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - epidemiology
Female
Fetal Death - virology
General aspects
Humans
Infectious diseases
Infertility - virology
Malaysia - epidemiology
Medical sciences
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Premature Birth - virology
Seroepidemiologic Studies
Viral diseases
Malaysia
Human
Prevalence
Herpesviridae
Serology
Betaherpesvirinae
Epidemiology
Human cytomegalovirus
Infection
Virus
Pregnancy
Viral disease
Complication
Female
Tropical medicine
Woman
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Summary:The objective of this study was to determine the seroprevalence of cytomegalovirus (CMV) infections through antenatal screening data and the association of this virus with obstetric complications. Serum samples from 125 apparently healthy pregnant women sent for antenatal screening from various hospitals in Malaysia between January 2007 and December 2008, were examined for CMV specific IgM and IgG antibodies using an enzyme-linked immunosorbent assay method. Of the 125 pregnant women tested, anti-CMV IgG antibody was found in 105 (84%) of the cases and anti-CMV IgM in 9 cases (7.2%). Both CMV IgM and IgG were also found in another 37 women whose serum samples were sent for investigation of various obstetric complications: 17 cases of spontaneous abortions, 15 cases of fetal anomalies detected during ultrasound examination, 1 case of incomplete abortion, 3 cases with premature delivery of infant with congenital anomalies and 1 case of infertility. Our preliminary data which only represented a small study group has shown the prevalence of CMV infection among the local population and the association of CMV in obstetric complications.
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ISSN:0125-1562