In-vitro activities of 16 non-β-lactam antibiotics against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae

• Published in: Journal of antimicrobial chemotherapy Vol. 43; no. 4; pp. 563 - 567
• Main Authors: VERHAEGEN, J, VERBIST, L
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.1999
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Drug Resistance, Microbial; Humans; Macrolides; Medical sciences; Microbial Sensitivity Tests; Penicillin Resistance; Penicillins - pharmacology; Pharmacology. Drug treatments; Pneumococcal Infections - microbiology; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - isolation & purification; Tetracycline Resistance; Tetracycline derivatives; β-Lactams; In vitro; Macrolide; Biological activity; Streptococcus pneumoniae; Penicillin derivatives; Streptococcaceae; Antibiotic; Fluoroquinolone derivatives; Microorganism resistance; Minimum inhibitory concentration; Penicillin; Bacteria; Micrococcales; Antibacterial agent; Quinolone derivatives
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/43.4.563

MICs of 16 non-beta-lactams were determined by agar dilution for 283 penicillin-susceptible, 122 intermediate and 23 fully penicillin-resistant isolates of pneumococci. Penicillin-resistant pneumococci were more likely to be resistant to tetracyclines, macrolides and related compounds. In the latter group, quinupristin/dalfopristin was the only compound whose activity was not influenced by penicillin resistance. Among the fluoroquinolones, clinafloxacin and trovafloxacin showed excellent activity. Strains resistant to macrolides, tetracycline and penicillin were concentrated in serogroups 6, 9, 14, 19 and 23.