Treatment of Chlamydia trachomatis identified with Chlamydiazyme during pregnancy. Impact on perinatal complications and infants

A rapid enzyme immunoassay antigen detection system (Chlamydiazyme) was used to screen 199 asymptomatic, third-trimester women. Fifty-two (26%) were Chlamydiazyme positive; they were mostly primiparous, single, young and black. Infected women were offered erythromycin therapy, counseling and postthe...

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Bibliographic Details
Published inJournal of reproductive medicine Vol. 35; no. 4; p. 362
Main Authors Black-Payne, C, Ahrabi, M M, Bocchini, Jr, J A, Ridenour, C R, Brouillette, R M
Format Journal Article
LanguageEnglish
Published United States 01.04.1990
Subjects
Adult
Chlamydia Infections - diagnosis
Chlamydia Infections - drug therapy
Chlamydia Infections - transmission
Chlamydia trachomatis
Endometritis - etiology
Erythromycin - therapeutic use
Female
Humans
Immunoenzyme Techniques
Infant, Newborn
Mass Screening - methods
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - drug therapy
Pregnancy Outcome
Pregnancy Trimester, Third
Prospective Studies
Puerperal Disorders - etiology
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Summary:A rapid enzyme immunoassay antigen detection system (Chlamydiazyme) was used to screen 199 asymptomatic, third-trimester women. Fifty-two (26%) were Chlamydiazyme positive; they were mostly primiparous, single, young and black. Infected women were offered erythromycin therapy, counseling and posttherapy retesting. Sexual partners were treated likewise. Erythromycin compliance, determined by a questionnaire, was high (92%), and side effects (16%) were tolerable. Pregnancy outcome and infant illnesses were monitored to determine the effectiveness of therapy. There were no significant differences in pregnancy outcome in the Chlamydiazyme-negative and treated, Chlamydiazyme-positive women. Prospective evaluation of infants born to 48 negative and 50 treated, Chlamydiazyme-positive women revealed no significant differences in the incidence of respiratory tract illnesses or conjunctivitis. Chlamydiazyme can be used in a screening program to identify and treat third-trimester women infected with C trachomatis. As previously reported, erythromycin therapy for colonized women interrupted the expected transmission of C trachomatis to their infants.
ISSN:0024-7758