Prevalence of FMR1 repeat expansions in movement disorders. A systematic review

We reviewed prevalence rates of fragile X mental retardation gene (FMR1) repeat expansions in movement disorder populations. Inclusion criteria included published epidemiological studies from systematic searches of Medline, Pubmed, Cochrane Databases and Web Science. Thirteen cross-sectional studies...

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Bibliographic Details
Published inNeuroepidemiology Vol. 26; no. 3; pp. 151 - 155
Main Authors Hall, D A, Hagerman, R J, Hagerman, P J, Jacquemont, S, Leehey, M A
Format Journal Article
LanguageEnglish
Published Switzerland S. Karger AG 01.04.2006
Subjects
Cross-Sectional Studies
DNA Repeat Expansion - genetics
Female
Fragile X Mental Retardation Protein - genetics
Humans
Male
Middle Aged
Movement Disorders - genetics
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Summary:We reviewed prevalence rates of fragile X mental retardation gene (FMR1) repeat expansions in movement disorder populations. Inclusion criteria included published epidemiological studies from systematic searches of Medline, Pubmed, Cochrane Databases and Web Science. Thirteen cross-sectional studies were carried out between 2003 and 2005. Subjects with ataxia showed higher than expected rates while those with essential tremor and parkinsonism showed lower rates. The heterogeneous design of the studies, inclusion criteria and mean age of subjects may have led to underestimation of FMR1 repeat expansion prevalence rates.
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ISSN:0251-5350
1423-0208
DOI:10.1159/000091656