Comparison of production of volatile hydrocarbons by phenylhydrazine-induced peroxidation in rats chronically treated with lead

We have studied the effect of a chronic pretreatment by lead on the peroxidation processes by measuring the production of the four main volatile hydrocarbons: ethane and pentane as index of lipid peroxidation; propane as marker of protein peroxidation and ethylene as index of both lipid and protein...

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Bibliographic Details
Published inResearch communications in chemical pathology and pharmacology Vol. 71; no. 1; p. 105
Main Authors Hafi, A, Cluet, J L, Pages, N, Fournier, G, Alcindor, R, Boudene, C
Format Journal Article
LanguageEnglish
Published United States 01.01.1991
Subjects
Animals
Female
Hydrocarbons - metabolism
Lead - toxicity
Lipid Peroxidation - drug effects
Male
Peroxides - metabolism
Phenylhydrazines - pharmacology
Proteins - metabolism
Rats
Rats, Inbred Strains
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Summary:We have studied the effect of a chronic pretreatment by lead on the peroxidation processes by measuring the production of the four main volatile hydrocarbons: ethane and pentane as index of lipid peroxidation; propane as marker of protein peroxidation and ethylene as index of both lipid and protein peroxidations. Our results have shown that: 1) lead alone did not increase the physiological formation of alkanes indicating that lead is not able per se to initiate the peroxidative processes; 2) after phenylhydrazine injection, lipid peroxidation makers were not modified, except pentane in male lead-treated rats. Conversely, ethylene and propane exhalation were increased 45 min after phenylhydrazine injection in lead-treated rats indicating a potentialisation of the oxidative effect of phenylhydrazine, mainly on proteins, by lead.
ISSN:0034-5164