Bacterial acetate metabolism and its influence on human epithelia

Short-chain fatty acids are known modulators of host-microbe interactions and can affect human health, inflammation, and outcomes of microbial infections. Acetate is the most abundant but least well-studied of these modulators, with most studies focusing on propionate and butyrate, which are conside...

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Bibliographic Details
Published inEmerging topics in life sciences Vol. 8; no. 1; p. 1
Main Authors Hosmer, Jennifer, McEwan, Alastair G, Kappler, Ulrike
Format Journal Article
LanguageEnglish
Published England 22.02.2024
Subjects
Acetates
Bacteria - metabolism
Butyrates
Fatty Acids, Volatile - metabolism
Humans
Propionates - metabolism
Propionates - pharmacology
acetate
microbiology
short-chain fatty acid
metabolism
host–microbe interactions
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ISSN2397-8554
DOI10.1042/ETLS20220092

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Summary:Short-chain fatty acids are known modulators of host-microbe interactions and can affect human health, inflammation, and outcomes of microbial infections. Acetate is the most abundant but least well-studied of these modulators, with most studies focusing on propionate and butyrate, which are considered to be more potent. In this mini-review, we summarize current knowledge of acetate as an important anti-inflammatory modulator of interactions between hosts and microorganisms. This includes a summary of the pathways by which acetate is metabolized by bacteria and human cells, the functions of acetate in bacterial cells, and the impact that microbially derived acetate has on human immune function.
ISSN:2397-8554
DOI:10.1042/ETLS20220092