Action of Sosiho-Tang on systemic and local anaphylaxis by anal administration

• Published in: Immunopharmacology and immunotoxicology Vol. 21; no. 3; p. 635
• Main Authors: Kim, H M, Kim, Y Y, Jang, H Y, Moon, S J, An, N H
• Format: Journal Article
• Language: English
• Published: England 01.08.1999
• Subjects: Administration, Rectal; Anaphylaxis - prevention & control; Animals; Anti-Allergic Agents - administration & dosage; Antibodies, Anti-Idiotypic - immunology; Histamine - blood; Korea; Medicine, East Asian Traditional; Mice; p-Methoxy-N-methylphenethylamine - pharmacology; Passive Cutaneous Anaphylaxis - drug effects; Plant Extracts; Korea
• ISSN: 0892-3973
• DOI: 10.3109/08923979909007131

The herbal formulation Soshiho-Tang (SS-Tang) has been used against allergic disease for generations, and still occupies an important place in traditional medicine in Korea. Previously, we reported that SS-Tang potently inhibited mast cell- mediated anaphylaxis when orally administered. In this study, we investigated the effect of SS-Tang by anal administration in anaphylaxis responses. SS-Tang dose-dependently inhibited compound 48/80-induced systemic anaphylaxis with doses of 10(-4) to 1 g/kg 1 h before anally administered. Of special note, SS-Tang inhibited systemic anaphylaxis completely with a dose of 1 g/kg. SS-Tang reduced plasma histamine levels induced by compound 48/80 significantly. However, the mortality was 100% when SS-Tang was administered after compound 48/80 treatment. SS-Tang (10(-1) g/kg) also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE antibody by 30.9%. These results provide evidence that anal therapy of SS-Tang may be beneficial in the treatment of systemic and local anaphylaxis.