The antibacterial activity of plaunotol against Staphylococcus aureus isolated from the skin of patients with atopic dermatitis

Plaunotol was tested for possible antibacterial activity against twenty strains of methicillin-resistant Staphylococcus aureus (MRSA) and fourteen strains of methicillin-sensitive S. aureus (MSSA) which had been isolated from the skin of patients with atopic dermatitis under growth-promoting conditi...

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Bibliographic Details
Published inMicrobios Vol. 96; no. 385; p. 149
Main Authors Matsumoto, Y, Hamashima, H, Masuda, K, Shiojima, K, Sasatsu, M, Arai, T
Format Journal Article
LanguageEnglish
Published England 1998
Subjects
Anti-Bacterial Agents - pharmacology
Dermatitis, Atopic - microbiology
Drug Resistance, Microbial
Fatty Alcohols - pharmacology
Humans
Methicillin - pharmacology
Skin - microbiology
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
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Summary:Plaunotol was tested for possible antibacterial activity against twenty strains of methicillin-resistant Staphylococcus aureus (MRSA) and fourteen strains of methicillin-sensitive S. aureus (MSSA) which had been isolated from the skin of patients with atopic dermatitis under growth-promoting conditions. Plaunotol was effective against all strains tested. The dose of plaunotol for 50% inhibition of growth (ID50) ranged from 2.5 to 16 micrograms/ml for strains of MRSA and from 2.5 to 7.0 micrograms/ml for those of MSSA. These results suggest that plaunotol may be useful in the prevention of infection by MRSA and in skin care for patients with atopic dermatitis.
ISSN:0026-2633