Assignment of the uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization

The Uroplakin 1B protein, a terminal differentiation product of the urothelial asymmetric unit membrane on the bladder apical surface, is in the tetraspan family of proteins. UPK1B localizes to human 3q13.3 arrow right q21 and cattle chromosome 1. Mouse Upk1b is syntenic with a number of genes in th...

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Published inCytogenetics and cell genetics Vol. 84; no. 1-2; pp. 37 - 38
Main Authors WEBB, G. C, FINCH, J. L, COWLED, P. A
Format Journal Article
LanguageEnglish
Published Freiburg Karger 1999
Basel
Paris
Subjects
Animals
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
In Situ Hybridization
Membrane Glycoproteins - genetics
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Tetraspanins
Uroplakin Ib
Vertebrata
Genetic mapping
Vertebrata
Mammalia
Mouse
Chromosome 16
Rodentia
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Summary:The Uroplakin 1B protein, a terminal differentiation product of the urothelial asymmetric unit membrane on the bladder apical surface, is in the tetraspan family of proteins. UPK1B localizes to human 3q13.3 arrow right q21 and cattle chromosome 1. Mouse Upk1b is syntenic with a number of genes in the mouse and human. In particular CD80, at human 3q13.3 arrow right q21 and mouse 16B5 and 28.0 cM, indicates Upk1b would map around 30 cM. UPK1B is a non-housekeeping gene and should be in a dark G band; in humans and mice the gene is so close to the interface of grey and light G-bands that this remains uncertain.
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ISSN:0301-0171
DOI:10.1159/000015208