NRAMP1/SLC11A1 GENE POLYMORPHISMS AND HOST SUSCEPTIBILITY TO MYCOBACTERIUM TUBERCULOSIS AND M. LEPRAE IN SOUTH SULAWESI, INDONESIA

Genetic host factor may play an important role in controlling mycobacterial infections such as tuberculosis and leprosy. Natural resistance associated macrophage protein1 (Nramp1, alias Slc11a1) gene has been suggested to an associated gene of the host susceptibility to mycobacterium infection. To d...

Full description

Saved in:
Bibliographic Details
Published inSoutheast Asian journal of tropical medicine and public health Vol. 41; no. 2; pp. 386 - 394
Main Authors HATTA, Mochammad, RATNAWATI, TANAKA, Motoko, ITO, Jun, SHIRAKAWA, Toshiro, KAWABATA, Masato
Format Journal Article
LanguageEnglish
Published Bangkok SEAMO, Regional Tropical Medicine and Public Health Network 01.03.2010
Central Coordinating Board, SEAMEO-TROPMED Project
Subjects
Adult
Biological and medical sciences
Case-Control Studies
Cation Transport Proteins - genetics
Chi-Square Distribution
Female
General aspects
Genetic Predisposition to Disease
Humans
Indonesia - epidemiology
Leprosy - epidemiology
Leprosy - genetics
Male
Medical sciences
Mycobacterium leprae - genetics
Mycobacterium tuberculosis - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - genetics
Asia
Indonesia
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacteriales
Mycobacteriaceae
Bacteria
Tropical medicine
Actinomycetes
Polymorphism
Online AccessGet full text

Cover

More Information
Summary:Genetic host factor may play an important role in controlling mycobacterial infections such as tuberculosis and leprosy. Natural resistance associated macrophage protein1 (Nramp1, alias Slc11a1) gene has been suggested to an associated gene of the host susceptibility to mycobacterium infection. To determine the association of Nramp1/Slc11a1 with tuberculosis and leprosy, we analyzed using polymerase chain reaction restriction fragment length polymorphisms three variants (D543N, 3'UTR and INT4) of Nramp1/Slc11a1 gene in 58 tuberculosis patients (mean age, 34.0 +/- 13.1), 42 leprosy patients (mean age, 35.0 +/- 14.3) and 198 healthy controls (mean age, 32.0 +/- 12.9) from South Sulawesi, Indonesia. We observed an association of INT4 polymorphism with paucibacillary type of leprosy (p = 0.032, 1df, OR = 2.975, CI = 1.057-8.373), but not to multibacillary type (p = 0.173, 1df, OR = 2.248, CI = 0.682-7.404). No significant association was found in the three variants with tuberculosis in this population.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0125-1562