Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma

To assess the clinicopathological, immunohistochemical and molecular features of metanephric adenoma (MA). Clinicopathologic data were obtained for 5 cases of MA with follow-up information. Specimens from these patients were stained by HE and immunohistochemistry for the detection of WT1, vimentin,...

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Published inInternational journal of clinical and experimental pathology Vol. 8; no. 6; pp. 6031 - 6036
Main Authors Sun, Zhulei, Kan, Shihai, Zhang, Leilei, Zhang, Yan, Jing, Hong, Huang, Gui, Yu, Qichun, Wu, Jiang
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2015
Subjects
Adenoma - chemistry
Adenoma - genetics
Adenoma - pathology
Adenoma - surgery
Adult
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Kidney Neoplasms - chemistry
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Middle Aged
Nephrectomy
Original
Predictive Value of Tests
Tomography, X-Ray Computed
Tumor Burden
FISH
immunohistochemistry
molecular pathology
Metanephric adenoma
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Summary:To assess the clinicopathological, immunohistochemical and molecular features of metanephric adenoma (MA). Clinicopathologic data were obtained for 5 cases of MA with follow-up information. Specimens from these patients were stained by HE and immunohistochemistry for the detection of WT1, vimentin, S-100 protein, CK7, P504s, CD10 and renal cell carcinoma marker (RCC). Fluorescence in situ hybridization (FISH) was performed on 4 tumors. The patients included 1 male and 4 females, aged from 30 to 49 (mean=39) years. Tumor diameters ranged from 3 to 5.5 cm. Histologically, the tumors had tubular, papillary, or glomeruloid architectures, and were composed of cells with uniform and round nuclei, inconspicuous nucleoli, and high ratio of nucleus to cytoplasm. Nuclear polymorphism and mitotic figures were not observed. Immunohistochemically, they expressed WT1 (5/5), vimentin (5/5), S-100 (4/5), CK7 (2/5), P504s (2/5), and CD10 (1/5) and not RCC. FISH study was carried out on 4 metanephric adenoma cases, and no abnormalities were observed in chromosomes 3, 7, 17, and P16 gene of chromosomes 9. MA is an uncommon renal tumor. Its diagnosis depends on morphological, immunohistochemical and molecular features.
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Equal contributors and co-first authors.
ISSN:1936-2625