Chitosan based hydrogels: characteristics and pharmaceutical applications
Hydrogel scaffolds serve as semi synthetic or synthetic extra cellular matrix to provide an amenable environment for cellular adherence and cellular remodeling in three dimensional structures mimicking that of natural cellular environment. Additionally, hydrogels have the capacity to carry small mol...
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| Published in | Research in pharmaceutical sciences Vol. 10; no. 1; pp. 1 - 16 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Iran
Medknow Publications & Media Pvt Ltd
01.01.2015
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| Abstract | Hydrogel scaffolds serve as semi synthetic or synthetic extra cellular matrix to provide an amenable environment for cellular adherence and cellular remodeling in three dimensional structures mimicking that of natural cellular environment. Additionally, hydrogels have the capacity to carry small molecule drugs and/or proteins, growth factors and other necessary components for cell growth and differentiation. In the context of drug delivery, hydrogels can be utilized to localize drugs, increase drugs concentration at the site of action and consequently reduce off-targeted side effects. The current review aims to describe and classify hydrogels and their methods of production. The main highlight is chitosan-based hydrogels as biocompatible and medically relevant hydrogels for drug delivery. |
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| AbstractList | Hydrogel scaffolds serve as semi synthetic or synthetic extra cellular matrix to provide an amenable environment for cellular adherence and cellular remodeling in three dimensional structures mimicking that of natural cellular environment. Additionally, hydrogels have the capacity to carry small molecule drugs and/or proteins, growth factors and other necessary components for cell growth and differentiation. In the context of drug delivery, hydrogels can be utilized to localize drugs, increase drugs concentration at the site of action and consequently reduce off-targeted side effects. The current review aims to describe and classify hydrogels and their methods of production. The main highlight is chitosan-based hydrogels as biocompatible and medically relevant hydrogels for drug delivery. |
| Author | Ahmadi, F Oveisi, Z Samani, S Mohammadi Amoozgar, Z |
| AuthorAffiliation | 1 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran 2 Department of Cancer Immunology and Aids, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, U.S.A |
| AuthorAffiliation_xml | – name: 1 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran – name: 2 Department of Cancer Immunology and Aids, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, U.S.A |
| Author_xml | – sequence: 1 givenname: F surname: Ahmadi fullname: Ahmadi, F organization: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran – sequence: 2 givenname: Z surname: Oveisi fullname: Oveisi, Z organization: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran – sequence: 3 givenname: S Mohammadi surname: Samani fullname: Samani, S Mohammadi organization: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran – sequence: 4 givenname: Z surname: Amoozgar fullname: Amoozgar, Z organization: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran ; Department of Cancer Immunology and Aids, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, U.S.A |
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| Keywords | Crosslinking Drug delivery Chitosan Hydrogel Tissue engineering |
| Language | English |
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| Title | Chitosan based hydrogels: characteristics and pharmaceutical applications |
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