Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature

An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis...

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Published inInternational journal of clinical and experimental pathology Vol. 8; no. 2; pp. 1826 - 1829
Main Authors Mao, Song, Xuan, Xiaoyan, Sha, Yugen, Zhao, Sanlong, Zhang, Aihua, Huang, Songming
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2015
Subjects
Acute Disease
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biomarkers - analysis
Biopsy
Child
Complement C3 - analysis
Drug Therapy, Combination
Female
Fluorescent Antibody Technique
Glomerulonephritis - diagnosis
Glomerulonephritis - drug therapy
Glomerulonephritis - immunology
Humans
Immunosuppressive Agents - therapeutic use
Kidney Glomerulus - drug effects
Kidney Glomerulus - immunology
Kidney Glomerulus - ultrastructure
Microscopy, Electron
Original
Remission Induction
Streptococcal Infections - complications
Streptococcal Infections - diagnosis
Streptococcal Infections - immunology
Time Factors
Treatment Outcome
C3
deposition
Crescentic poststreptococcal acute glomerulonephritis
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Summary:An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine. The complete clinical remission was achieved after 9 months. No serious adverse effects were observed during the follow-up. Our findings indicated that CPAGN with isolated C3 deposition might have a favorable prognosis after aggressive immunosuppressive treatment. However, the influence of isolated C3 deposition on CPAGN prognosis remains to be clarified.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
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ISSN:1936-2625