Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical cancer

• Published in: International journal of clinical and experimental medicine Vol. 8; no. 2; pp. 2108 - 2117
• Main Authors: Wang, Lanling, Ma, Kunpeng, Wang, Zhiyong, Mou, Yingying, Ma, Li, Guo, Yong
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2015
• Subjects: Original; TNF-α; rs1800629; cervical cancer
• ISSN: 1940-5901; 1940-5901

The objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer. A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI). Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians. Our results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-α rs1800629 polymorphism.