Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum

During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric o...

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Published inEXCLI journal Vol. 14; pp. 1116 - 1121
Main Authors Ham, Young Min, Yoon, Weon-Jong, Lee, Wook Jae, Kim, Sang-Cheol, Baik, Jong Seok, Kim, Jin Hwa, Lee, Geun Soo, Lee, Nam Ho, Hyun, Chang-Gu
Format Journal Article
LanguageEnglish
Published Germany Leibniz Research Centre for Working Environment and Human Factors 01.01.2015
Subjects
Original
Sargassum micracanthum
brown alga
inflammation
isoketochabrolic acid
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Summary:During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.
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ISSN:1611-2156
1611-2156
DOI:10.17179/excli2015-555