Relationship between serum and synovial fluid CCL20 concentrations with disease severity in primary knee osteoarthritis

• Published in: Journal of musculoskeletal & neuronal interactions Vol. 19; no. 3; pp. 326 - 332
• Main Authors: Guan, Jian, Li, Yao, Ding, Luo-Bin, Liu, Guang-Yuan, Zheng, Xiao-Fei, Xue, Wei, Wang, Hua-Jun
• Format: Journal Article
• Language: English
• Published: Greece International Society of Musculoskeletal and Neuronal Interactions 01.09.2019
• Subjects: Original; Knee Osteoarthritis; Chemokine C-C Motif Ligand 20; Biomarker; Disease Severity; Macrophage Inflammatory Protein 3α
• ISSN: 1108-7161

The current study was performed to examine serum and synovial fluid (SF) CCL20 levels and their correlations with disease severity in primary knee osteoarthritis patients. A total of 99 patients diagnosed with primary knee OA were enrolled in the study, and 95 healthy individuals receiving regular medical examination were recruited as controls. Serum and SF CCL20 concentrations were determined using an enzyme-linked immunosorbent assay. The radiographic severity of OA was assessed by the Kellgren-Lawrence (K-L) classification system. The Lequesne algofunctional index and a visual analogue scale (VAS) were used to evaluate the clinical severity of knee OA in patients. The serum CCL20 levels were not significantly different between patients with knee OA and controls. Patients with a K-L grade of 4 had significantly higher SF CCL20 levels than those with K-L grades of 2 and 3. Knee OA patients with a K-L grade of 3 showed significantly higher levels of CCL20 in SF than those with a K-L grade of 2. In addition, SF CCL20 levels were significantly related to the Lequesne algofunctional index and VAS score. These findings suggest that local CCL20 levels may reflect the disease severity of knee OA.