Peripheral neuropathy and testosterone

A 265 lb. (body mass index, 38.1) male elite bodybuilder suffered focal muscle atrophy that developed in his right vastus lateralis muscle within a month following a painful self-administered injection of testosterone. The subject did not lose any sensory or motor function immediately after the inje...

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Bibliographic Details
Published inNeurotoxicology (Park Forest South) Vol. 18; no. 2; p. 587
Main Authors Dickerman, R D, Kramer, E, Pertusi, R, McConathy, W J
Format Journal Article
LanguageEnglish
Published Netherlands 1997
Subjects
Adult
Electromyography
Humans
Male
Muscular Atrophy - chemically induced
Muscular Atrophy - physiopathology
Paresthesia - chemically induced
Physical Education and Training
Testosterone - adverse effects
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Summary:A 265 lb. (body mass index, 38.1) male elite bodybuilder suffered focal muscle atrophy that developed in his right vastus lateralis muscle within a month following a painful self-administered injection of testosterone. The subject did not lose any sensory or motor function immediately after the injection; however after several days to weeks, muscle atrophy and paresthesia ensued. The subject had an obvious atrophic zone in the right vastus lateralis muscle with approximately 40% loss of strength when compared to the left leg. In our view, the neuropraxia developed from direct neurotoxic effect of androgens or pressure exerted upon the nerve following injection of a bolus of liquid. This report is indicative of the many potential dangers associated with unsupervised androgen use which may include androgens as potential neurotoxins.
ISSN:0161-813X