HLA class II (DRB1, DQA1 and DQB1) allele and haplotype frequencies among HIV-infection discordant Thai couples

• Published in: Asian Pacific journal of allergy and immunology Vol. 22; no. 2-3; pp. 143 - 151
• Main Authors: Bejrachandra, Sasitom, Kitayaporn, Dwip, Kaewkungwal, Jaranit, Piya-Anant, Manee, Permpikul, Parichart, Sirikong, Monchan, Siriboonrit, Usanee, Chandanayingyong, Dasnayanee
• Format: Journal Article
• Language: English
• Published: Thailand The Allergy and Immunology Society 01.06.2004
• Subjects: Alleles; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Histocompatibility Antigens Class II - genetics; HIV Infections - genetics; HLA-DQ alpha-Chains; HLA-DQ Antigens - genetics; HLA-DQ beta-Chains; HLA-DR Antigens - genetics; HLA-DRB1 Chains; Human immunodeficiency virus; Humans; Male; Pilot Projects; Risk Factors; Thailand; Thailand
• ISSN: 0125-877X

We investigated the association of HLA-DRB1, -DQA1 and -DQB1 alleles and haplotypes in 33 Thai HIV discordant couples. A significantly lower frequencies of DRB1*14 (3.0% vs 11.3%, p = 0.048) and DQA1*0103 (0.0% vs 5.63%, p = 0.042) alleles were found in the seropositive individuals when compared with HIV-negative controls. In contrast, there was no significant difference in HLA-DQB1* allele frequencies. The haplotype analysis revealed that DRB1*1501-DQA1*0102-DQB1*0601 (7.6% vs 0.0%, p = 0.002), DRB1*0405-DQA1*0302-DQB1*0401 (7.6% vs 1.3%, p = 0.024) and DRB1*1401-DQA1*0104-DQB1*05031 (6.1% vs 0.0%, p = 0.007) were found to be significantly higher frequencies when compared between HIV seronegative partners and HIV negative controls, but DRB1*1501-DQA1*0102-DQB1*0502 (0.0% vs 8.1%, p = 0.01) was significantly lower. The DRB1*1602-DQA1*0101-DQB1*0502 (4.6% vs 0.0%, p = 0.024) haplotype was found to be significantly higher frequencies in HIV seropositive individuals when compared to HIV negative controls but the DRB1*1502-DQA1*0101-DQB1*0501 (1.5% vs 8.1%, p = 0.049) haplotype was lower.