Stereotactic body radiation therapy induced myonecrosis in a patient with prior gemcitabine administered for leiomyosarcoma

We present the case of radiation myonecrosis of the iliopsoas muscle, identified five months after stereotactic body radiation therapy (SBRT, 21 Gy in three fractions) to a metastatic lesion in the right iliac bone of a patient with leiomyosarcoma. The patient had been treated with various chemother...

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Bibliographic Details
Published inJournal of radiosurgery and SBRT Vol. 7; no. 1; pp. 77 - 80
Main Authors Facer, Benjin D, Dutta, Sunil W, Showalter, Timothy N
Format Journal Article
LanguageEnglish
Published United States Old City Publishing, Inc 2020
Subjects
Short Communication
Complication
Myonecrosis
sarcoma
Gemcitabine
Radiation
SBRT
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Summary:We present the case of radiation myonecrosis of the iliopsoas muscle, identified five months after stereotactic body radiation therapy (SBRT, 21 Gy in three fractions) to a metastatic lesion in the right iliac bone of a patient with leiomyosarcoma. The patient had been treated with various chemotherapeutic agents, most notably docetaxel and gemcitabine for five cycles 10 months prior to SBRT. As skeletal muscle is a radio-resistant organ, myonecrosis is rare, but previous case reports suggest that the administration of gemcitabine may increase the likelihood of radiation toxicity, including radiation myonecrosis. Physicians may consider conventional fractionation, rather than a hypofractionated course, in patients who have received or will receive gemcitabine.
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ISSN:2156-4639
2156-4647