Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis: case report and literature review

The synchronous or metachronous development of Langerhans cell histiocytosis and non-Langerhans cell histiocytosis in the same patient is rare. To date, only seven cases of xanthogranulomas developing in young patients with a history of Langerhans cell histiocytosis and systemic therapy have been re...

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Bibliographic Details
Published inInternational journal of clinical and experimental pathology Vol. 5; no. 7; pp. 720 - 725
Main Authors Strehl, Johanna D, Stachel, Klaus-Daniel, Hartmann, Arndt, Agaimy, Abbas
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2012
Subjects
Antineoplastic Agents, Phytogenic - therapeutic use
Case Report
Child, Preschool
Eyelid Diseases - etiology
Eyelid Diseases - pathology
Eyelid Diseases - surgery
Forehead
Glucocorticoids - therapeutic use
Histiocytosis, Langerhans-Cell - drug therapy
Humans
Male
Prednisone - therapeutic use
Treatment Outcome
Vinblastine - therapeutic use
Xanthogranuloma, Juvenile - etiology
Xanthogranuloma, Juvenile - pathology
Xanthogranuloma, Juvenile - surgery
coincidence
juvenile xanthogranuloma
Langerhans cell histiocytosis
synchronous
metachronous
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Summary:The synchronous or metachronous development of Langerhans cell histiocytosis and non-Langerhans cell histiocytosis in the same patient is rare. To date, only seven cases of xanthogranulomas developing in young patients with a history of Langerhans cell histiocytosis and systemic therapy have been reported in the literature. As of yet, the pathogenesis and the clinical significance of this phenomenon are unclear. We report the case of a 3 year old boy who developed juvenile Xanthogranulomas on the forehead and right upper eye lid 1.5 years after systemic therapy for monosystemic Langerhans cell histiocytosis of the bone and complete disease remission.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:1936-2625