A meta-analysis of platelet gel for prevention of sternal wound infections following cardiac surgery

Deep sternal wound infection and bleeding are devastating complications following cardiac surgery, which may be reduced by topical application of autologous platelet gel. Systematic review identified seven comparative studies involving 4,692 patients. Meta-analysis showed significant reductions in a...

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Published inBlood transfusion = Trasfusione del sangue Vol. 15; no. 1; pp. 57 - 65
Main Authors Kirmani, Bilal H, Jones, Siôn G, Datta, Subir, Mclaughlin, Edward K, Hoschtitzky, Andreas J
Format Journal Article
LanguageEnglish
Published Italy Edizioni SIMTI - SIMTI Servizi Srl 01.01.2017
Subjects
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - methods
Humans
Platelet-Rich Plasma - metabolism
Review
Sternum - microbiology
Sternum - surgery
Surgical Wound Infection - etiology
Surgical Wound Infection - prevention & control
Treatment Outcome
Wound Healing
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Summary:Deep sternal wound infection and bleeding are devastating complications following cardiac surgery, which may be reduced by topical application of autologous platelet gel. Systematic review identified seven comparative studies involving 4,692 patients. Meta-analysis showed significant reductions in all sternal wound infections (odds ratio 3.48 [1.08-11.23], p=0.04) and mediastinitis (odds ratio 2.69 [1.20-6.06], p=0.02) but not bleeding. No adverse events relating to the use of topical platelet-rich plasma were reported. The use of autologous platelet gel in cardiac surgery appears to provide significant reductions in serious sternal wound infections, and its use is unlikely to be associated with significant risk.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-4
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ISSN:1723-2007
DOI:10.2450/2016.0231-15