Lipids, liposomes, and rational drug design

Over 25 years ago, Alec Bangham reported on the diffusion of univalent ions across the lamellae of swollen phospholipids. These structures, which he called smectic mesophases, were in fact closed vesicles, spectacularly apparent under polarized light, able to sequester a captured volume and conseque...

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Bibliographic Details
Published inLaboratory investigation Vol. 66; no. 6; pp. 655 - 658
Main Author Janoff, A S
Format Journal Article
LanguageEnglish
Published New York, NY Nature Publishing 01.06.1992
Subjects
Biological and medical sciences
carriers
Drug Carriers
Drug Design
drugs
General pharmacology
Lipids
Liposomes
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
reviews
utilization
Design
Encapsulation
Drug
Pharmaceutical technology
Controlled release form
Liposome
Lipids
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Summary:Over 25 years ago, Alec Bangham reported on the diffusion of univalent ions across the lamellae of swollen phospholipids. These structures, which he called smectic mesophases, were in fact closed vesicles, spectacularly apparent under polarized light, able to sequester a captured volume and consequently able to shrink and swell under applied osmotic pressure differentials.
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ISSN:0023-6837
1530-0307