Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation

This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The...

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Bibliographic Details
Published inCaspian journal of internal medicine Vol. 4; no. 2; pp. 627 - 635
Main Author Hajian-Tilaki, Karimollah
Format Journal Article
LanguageEnglish
Published Iran Babol University of Medical Sciences 01.01.2013
Subjects
Review
Nonparametric
Sensitivity
Specificity
Area under the curve (AUC)
Bias
Parametric
ROC curve
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Summary:This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies, the advantage of ROC curve to determine the optimal cut off values and the issues of bias and confounding have been discussed.
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ISSN:2008-6164
2008-6172