Factors affecting overall survival in 51 adult Filipino patients undergoing stereotactic radiosurgery for spine metastases

• Published in: Journal of radiosurgery and SBRT Vol. 8; no. 3; pp. 175 - 180
• Main Authors: Ibet Marie, Y Sih, Erickson, F Torio, Maurice, V Bayhon, Jonna Mae, D Maala, Manuel, M Mariano, Rhoderick, M Casis, Carlo, G Barredo, Juan Manuel, L Mariano, Jo-Celine, M Leong, Charlene Mary, C Mercado, Jan Rehino, M Yanto, Juan Martin, J Magsanoc, Angela, P Camacho, Miriam Joy, C Calaguas, Thomas Vincent, T Vergara, Julius Cezar, P Rojales, Kathleen Jane, U Cortez, Ma Socorro, S D Santos, Roy, G Torcuator
• Format: Journal Article
• Language: English
• Published: United States Old City Publishing, Inc 2022
• Subjects: Clinical Investigation; overall survival; Stereotactic radiosurgery; cardiovascular disease; spine metastasis; visceral tumor origin
• ISSN: 2156-4639; 2156-4647

Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine. This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team. A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64,  = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ (5, N = 51) = 11.11 (  = 0.049)]. The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.