Overdominant vs. frequency-dependent selection at MHC loci

The relative roles of overdominant and frequency-dependent selection in the maintenance of polymorphism at major histocompatibility complex loci are discussed. Overdominance predicts a stable polymorphism whereas a polymorphism maintained by frequency dependence will be dynamic.

Saved in:
Bibliographic Details
Published inGenetics (Austin) Vol. 132; no. 3; pp. 861 - 862
Main Authors Slade, Robert W, McCallum, Hamish I
Format Journal Article
LanguageEnglish
Published Bethesda Genetics Society of America 01.11.1992
Subjects
Genetics
Letters to the Editor
Online AccessGet full text

Cover

More Information
Summary:The relative roles of overdominant and frequency-dependent selection in the maintenance of polymorphism at major histocompatibility complex loci are discussed. Overdominance predicts a stable polymorphism whereas a polymorphism maintained by frequency dependence will be dynamic.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0016-6731
1943-2631