How do tumor necrosis factor receptors work ?

Quite suddenly, a new level of understanding has been attached to the TNF ligand and receptor families. Many of the proximal transducers that signal the presence of TNF or its homologs have been identified, and certain components of the distal signaling pathway have emerged as well. We lack, however...

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Bibliographic Details
Published inJournal of inflammation Vol. 45; no. 4; pp. 221 - 238
Main Authors BAZZONI, F, BEUTLER, B
Format Journal Article
LanguageEnglish
Published New York, NY Wiley-Liss 1995
Subjects
Animals
Biological and medical sciences
Cell receptors
Cell structures and functions
Crystallography
Fundamental and applied biological sciences. Psychology
Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors
Humans
Models, Biological
Molecular and cellular biology
Molecular Conformation
Receptors, Tumor Necrosis Factor - chemistry
Receptors, Tumor Necrosis Factor - physiology
Signal Transduction
Tumor Necrosis Factor-alpha - physiology
Human
Ligand binding
Signal transduction
Molecular structure
Tumor necrosis factor
Cytokine
Review
Biological effect
Mechanism of action
Modeling
Cell surface
Biological receptor
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Summary:Quite suddenly, a new level of understanding has been attached to the TNF ligand and receptor families. Many of the proximal transducers that signal the presence of TNF or its homologs have been identified, and certain components of the distal signaling pathway have emerged as well. We lack, however, a "movie" of the events that transpire when TNF binds its receptors on the surface of a cell. The facts in hand permit an educated approximation.
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ISSN:1078-7852