Bacterial Haemoprotein Sensors of NO: H-NOX and NosP

Low concentrations of nitric oxide (NO) modulate varied behaviours in bacteria including biofilm dispersal and quorum sensing-dependent light production. H-NOX (haem-nitric oxide/oxygen binding) is a haem-bound protein domain that has been shown to be involved in mediating these bacterial responses...

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Bibliographic Details
Published inAdvances in microbial physiology Vol. 70; pp. 1 - 36
Main Authors Bacon, Bezalel, Nisbett, Lisa-Marie, Boon, Elizabeth
Format Journal Article
LanguageEnglish
Published England 2017
Subjects
Signal transduction
Nitric oxide
Haemoprotein
NO sensor
Biofilm
NosP
H-NOX
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Summary:Low concentrations of nitric oxide (NO) modulate varied behaviours in bacteria including biofilm dispersal and quorum sensing-dependent light production. H-NOX (haem-nitric oxide/oxygen binding) is a haem-bound protein domain that has been shown to be involved in mediating these bacterial responses to NO in several organisms. However, many bacteria that respond to nanomolar concentrations of NO do not contain an annotated H-NOX domain. Nitric oxide sensing protein (NosP), a newly discovered bacterial NO-sensing haemoprotein, may fill this role. The focus of this review is to discuss structure, ligand binding, and activation of H-NOX proteins, as well as to discuss the early evidence for NO sensing and regulation by NosP domains. Further, these findings are connected to the regulation of bacterial biofilm phenotypes and symbiotic relationships.
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Authors contributed equally to this work.
ISSN:0065-2911
2162-5468
DOI:10.1016/bs.ampbs.2017.01.004