MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA

Although surgical treatment, chemotherapy, and radiotherapy have improved the overall survival rate in glioblastoma multiforme (GBM), further intensive research of GBM's molecular mechanism is still needed. In this study, we observed that miR-422a was downregulated in GBM tissues and cell lines...

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Published inAmerican journal of cancer research Vol. 6; no. 8; pp. 1695 - 1707
Main Authors Liang, Haiqian, Wang, Renjie, Jin, Ying, Li, Jianwei, Zhang, Sai
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2016
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Original
miR-422a
GBM
MicroRNA
PIK3CA
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Summary:Although surgical treatment, chemotherapy, and radiotherapy have improved the overall survival rate in glioblastoma multiforme (GBM), further intensive research of GBM's molecular mechanism is still needed. In this study, we observed that miR-422a was downregulated in GBM tissues and cell lines by quantitative real-time polymerase chain reaction (PCR) and primer extension assay. Overexpression of miR-422a significantly reduced the cell proliferation, migration, and invasion of GBM cells. Functional study indicated that miR-422a inhibited cell proliferation, invasion, and migration by targeting PIK3CA, an important member of PI3K/Akt signal pathway. These results demonstrate that the miR-422a/PIK3CA axis may constitute a potential target for GBM therapy.
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ISSN:2156-6976
2156-6976