Squamous cell carcinoma at maxillary sinus: clinicopathologic data in a single Brazilian institution with review of literature

Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. There are no studies describing specifically its epidemiology in the South America. The aim of the current paper is to characterize a Brazilian maxillary sinus sq...

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Published inInternational journal of clinical and experimental pathology Vol. 7; no. 12; pp. 8823 - 8832
Main Authors Santos, Marcello Roter M, Servato, João Paulo S, Cardoso, Sérgio Vitorino, de Faria, Paulo Rogério, Eisenberg, Ana Lúcia A, Dias, Fernando Luiz, Loyola, Adriano Mota
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2014
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Brazil - epidemiology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - pathology
Female
Humans
Male
Maxillary Sinus Neoplasms - epidemiology
Maxillary Sinus Neoplasms - pathology
Middle Aged
Original
Young Adult
Brazil
epidemiology
paranasal carcinoma
treatment
prognosis
Maxillary sinus
squamous cell carcinoma
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Summary:Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. There are no studies describing specifically its epidemiology in the South America. The aim of the current paper is to characterize a Brazilian maxillary sinus squamous cell carcinoma sample and to compare such data with others worldwide relevant series. The records of the Brazilian National Cancer Institute (1997-2006) were gathered and plotted. Additionally, an extensive literature review was carry out using electronic database (PUBMED/MEDLINE and LILACS) over a period of 54 years. A descriptive statistics and univariate survival test (log rank) were employed. Maxillary sinus squamous cell carcinoma was the commonest malignancy of sinonasal epithelium found. It affected mainly mid-age white men and most of them were diagnosed at advanced stage. Surgery combined with radiotherapy was the most therapeutic modalities given. The overall mortality rate in our sample was of 65.5%. Overall 1-, 2- and 5-year survival rate was 57.9%, 44.8%, and 17.7%, respectively. Maxillary sinus squamous cell carcinoma is an aggressive tumor normally diagnosed at the advanced stage and most patients present an unfavorable prognosis and reduced survival rate.
Bibliography:ObjectType-Article-2
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ISSN:1936-2625