Selective blockade of components of potassium activation in Myxicola axons

The K+ conductance in Myxicola giant axons activates in two phases which are pharmacologically separable. The fast phase of K+ activation is specifically inhibited by 4-aminopyridine and by the substitution of D2O for H2O. We suggest Myxicola giant axons, like the amphibian node of Ranvier, may poss...

Full description

Saved in:
Bibliographic Details
Published inExperientia Vol. 43; no. 2; p. 169
Main Authors Chuman, M A, Schauf, C L, Davis, F A, Stefoski, D
Format Journal Article
LanguageEnglish
Published Switzerland 15.02.1987
Subjects
4-Aminopyridine
Aminopyridines - pharmacology
Animals
Axons - drug effects
Axons - physiology
Deuterium
Deuterium Oxide
Electric Conductivity
Ion Channels - drug effects
Ion Channels - physiology
Kinetics
Polychaeta
Potassium - pharmacology
Water
Online AccessGet more information

Cover

More Information
Summary:The K+ conductance in Myxicola giant axons activates in two phases which are pharmacologically separable. The fast phase of K+ activation is specifically inhibited by 4-aminopyridine and by the substitution of D2O for H2O. We suggest Myxicola giant axons, like the amphibian node of Ranvier, may possess more than one variety of K+ channel.
ISSN:0014-4754
DOI:10.1007/BF01942838