Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease

Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by mutations in DNA damage-response pathway genes th...

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Bibliographic Details
Published inHeart failure clinics Vol. 18; no. 3; p. 349
Main Authors Yura, Yoshimitsu, Cochran, Jesse D, Walsh, Kenneth
Format Journal Article
LanguageEnglish
Published United States 01.07.2022
Subjects
Cardiovascular Diseases - etiology
Clonal Hematopoiesis - genetics
Hematopoiesis - genetics
Hematopoietic Stem Cells - metabolism
Humans
Neoplasms - complications
Cardio-oncology
Inflammation
Clonal hematopoiesis
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Summary:Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by mutations in DNA damage-response pathway genes that allow hematopoietic stem cells to undergo positive selection in response to the genotoxic stress. These mutant cells increasingly give rise to progeny leukocytes that display enhanced proinflammatory properties. Recent experimental studies suggest that therapy-related clonal hematopoiesis may contribute to the medium- to long-term risk of genotoxic therapies on the cardiovascular system.
ISSN:1551-7136
DOI:10.1016/j.hfc.2022.02.010