Indium-mediated Barbier-type allylation reaction in PEG400 and PEG400/H2O

A green method for the allylation of aldehydes with allyl bromide mediated by indium in polyethylene glycol 400 (PEG400) and PEG400/H2O is described. Aldehydes with different substituents afforded the corresponding homoallylic alcohols in good to excellent yields. Comparative studies show that water...

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Bibliographic Details
Published inJournal of chemical research Vol. 34; no. 8; pp. 475 - 477
Main Authors Du, Zhengyin, Wang, Fen, Zhou, Wanwei, Wang, Jin-Xian
Format Journal Article
LanguageEnglish
Published ST ALBANS Science Reviews 2000 Ltd 01.08.2010
Sage Publications Ltd
Subjects
Alcohols
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
SYSTEM
ORGANIC-SYNTHESIS
ORGANOMETALLIC REACTIONS
IMINES
homoallyl alcohols
AQUEOUS-MEDIA
indium
CARBONYL-COMPOUNDS
ALDEHYDES
aqueous reaction
green synthesis
PEG400
allylation
WATER
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Summary:A green method for the allylation of aldehydes with allyl bromide mediated by indium in polyethylene glycol 400 (PEG400) and PEG400/H2O is described. Aldehydes with different substituents afforded the corresponding homoallylic alcohols in good to excellent yields. Comparative studies show that water promoted this reaction in PEG 400.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1747-5198
2047-6507
DOI:10.3184/030823410X12813608471242