Serum erythropoietin titers in patients with human immunodeficiency virus (HIV) infection and anemia

The pathophysiology of anemia in patients with human immunodeficiency virus (HIV) infection is multifactorial. In order to determine the role of erythropoietin (EPO) response as a cause of the anemia, serum levels were determined by direct radioimmunoassay in 110 symptomatic patients with various st...

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Published inJournal of acquired immune deficiency syndromes (1988) Vol. 4; no. 6; p. 593
Main Authors Rarick, M U, Loureiro, C, Groshen, S, Sullivan-Halley, J, Gill, P S, Bernstein-Singer, M, Levine, A M
Format Journal Article
LanguageEnglish
Published United States 1991
Subjects
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - drug therapy
Adult
AIDS-Related Complex - blood
AIDS-Related Complex - complications
AIDS-Related Complex - drug therapy
Anemia - etiology
CD4-Positive T-Lymphocytes
Erythropoietin - blood
Hemoglobins - analysis
Humans
Leukocyte Count
Male
Middle Aged
Zidovudine - therapeutic use
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Summary:The pathophysiology of anemia in patients with human immunodeficiency virus (HIV) infection is multifactorial. In order to determine the role of erythropoietin (EPO) response as a cause of the anemia, serum levels were determined by direct radioimmunoassay in 110 symptomatic patients with various stages of HIV infection. Symptomatic patients (ARC and AIDS) not receiving zidovudine (ZDV) therapy demonstrated a strong inverse relationship between serum EPO and hemoglobin levels (p = 0.01 and p less than 0.001, respectively). Patients with AIDS who were anemic while receiving ZDV demonstrated serum EPO levels that ranged from normal to markedly elevated (9-3,390 mU/ml). The diversity of serum EPO levels in patients with HIV infection and anemia suggests that the etiology of anemia in these patients and their potential response to recombinant human EPO may not be uniform.
ISSN:0894-9255