The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3

The netrins define a family of chemotropic factors that have been shown to play a central role in axon guidance. We identified two exon traps encoding netrin-like sequences during the assembly of a transcriptional map for the genomic interval surrounding the polycystic kidney disease type 1 and tube...

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Published inGenomics (San Diego, Calif.) Vol. 41; no. 2; pp. 279 - 282
Main Authors VAN RAAY, T. J, FOSKETT, S. M, CONNORS, T. D, KLINGER, K. W, LANDES, G. M, BURN, T. C
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier 15.04.1997
Subjects
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 16
DNA, Complementary
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nerve Growth Factors - genetics
Netrins
Polycystic Kidney, Autosomal Dominant - genetics
Sequence Homology, Amino Acid
Genetic mapping
Human
Nucleotide sequence
Netrin
Axon
Homology
Gene organization
Nervous system
Gene expression
Chemotactic factor
Chromosome E16
Gene
Domain structure
Chromosome DNA
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Summary:The netrins define a family of chemotropic factors that have been shown to play a central role in axon guidance. We identified two exon traps encoding netrin-like sequences during the assembly of a transcriptional map for the genomic interval surrounding the polycystic kidney disease type 1 and tuberous sclerosis type 2 genes. We describe the characterization of a novel human netrin-2-like gene, designated NTN2L, and its transcript. The genomic interval containing the NTN2L gene was sequenced, and the coding region was predicted based on computer analysis. The structure of the NTN2L gene has been confirmed utilizing nested RT-PCR. The NTN2L gene is predicted to encode a 580-amino-acid protein having homology to the chicken and Drosophila netrins and to Caenorhabditis elegans UNC-6. The NTN2L gene has a restricted pattern of expression; its transcript is undetectable by Northern analysis in all tissues examined, but can be recovered from spinal cord RNA by RT-PCR. This report represents the first description and characterization of a human netrin.
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ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1997.4659