FLOT-2 is an independent prognostic marker in oral squamous cell carcinoma

• Published in: International journal of clinical and experimental pathology Vol. 8; no. 7; pp. 8236 - 8243
• Main Authors: Wen, Qiuyuan, Alnemah, Mohannad Ma, Luo, Jiadi, Wang, Weiyuan, Chu, Shuzhou, Chen, Lingjiao, Li, Jiao, Xu, Lina, Li, Meirong, Zhou, Jianhua, Fan, Songqing
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2015
• Subjects: Alcohol Drinking - adverse effects; Biomarkers, Tumor - analysis; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Chi-Square Distribution; Female; Head and Neck Neoplasms - chemistry; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - surgery; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Membrane Proteins - analysis; Middle Aged; Mouth Neoplasms - chemistry; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Multivariate Analysis; Original; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Risk Factors; Squamous Cell Carcinoma of Head and Neck; Tissue Array Analysis; Up-Regulation; Oral squamous cell carcinoma (OSCC); immunohistochemistry; biomarker; prognosis; flotillin-2 (flot-2)
• ISSN: 1936-2625

Flotillin-2 (Flot-2) is an important component of cellular membrane, which involves in various cellular processes and recent studies have revealed that Flot-2 played important roles in cancer progression. The expression and prognostic impact of Flot-2 in oral squamous cell carcinoma (OSCC) have not been well studied. So, a tissue microarray (TMA) based on immunohistochemical analysis of surgical resection of tumor tissues of 78 cases of OSCC patients and 27 cases of adjacent non-cancerous squamous epithelium tissues was conducted. This study focused on detecting Flot-2 expression and analyzing its prognostic impact on OSCC. The result showed that the positive percentage of Flot-2 expression in OSCC (74.4%, 58/78) was significantly higher than that in adjacent non-cancerous squamous epithelium tissues (25.9%, 7/27) (P<0.001). Additionally, the positive expression of Flot-2 in OSCC patients with a history of alcohol consumption was significantly higher than those nonusers (P=0.027). Both univariate and multivariate survival analysis indicated that increased expression Flot-2 protein was significantly correlated inversely with overall survival rates in OSCC patients (P=0.046, P=0.002). Taken together, positive expression of Flot-2 protein may be an independent biomarker for poor prognosis in OSCC.