Bone-muscle indices as risk factors for fractures in men: the Osteoporotic Fractures in Men (MrOS) Study
To assess bone-muscle (B-M) indices as risk factors for incident fractures in men. Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle ar...
Saved in:
Published in | Journal of musculoskeletal & neuronal interactions Vol. 14; no. 3; pp. 246 - 254 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
01.09.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.
Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.
In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m(2), 4.1±0.9 follow-up years, 7.7% of men ⋝1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.
Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Steven Cummings scummings@sfcc-cpmc.net Moira Petit mpetit@umn.edu Katherine Wilt Peters kpeters@sfcc-cpmc.net Peggy Mannen Cawthon pcawthon@sfcc-cpmc.net Jane Cauley jcauley@edc.pitt.edu Kristine Ensrud ensru001@tc.umn.edu Joseph Zmuda zmudaj@edc.pitt.edu Eric Orwoll orwoll@ohsu.edu Christopher Gordon chrisgordon@sympatico.ca Yahtyng Sheu sheuy@edc.pitt.edu |
ISSN: | 1108-7161 |