Myostimulating effect of sesamum radiatum aqueous leaf extract in isolated Guinea-pig Taenia caeci contractile activity

This study was carried to examine the effects of the aqueous leaf extract of Sesamum radiatum, a laxative plant on the contractile activity of Taenia caeci, an intestinal smooth muscle. Strips of Taenia caeci were rapidly removed from guinea-pig and were suspended between two L-shaped stainless stee...

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Published inAfrican journal of traditional, complementary, and alternative medicines Vol. 8; no. 4; pp. 377 - 385
Main Authors Konan, André B, Amonkan, Augustin K, Ahui, Marie-Louise B, Bouafou, Guy-Marcel K, Kouakou, Léandre K, Kpahé, Fidèle Z, Datté, Jacques Y
Format Journal Article
LanguageEnglish
Published Nigeria African Networks on Ethnomedicines 01.01.2011
Subjects
Acetylcholine - antagonists & inhibitors
Animals
Atropine - pharmacology
Calcium - pharmacology
Cecum - drug effects
Cecum - physiology
Dose-Response Relationship, Drug
Female
Guinea Pigs
In Vitro Techniques
Isometric Contraction - drug effects
Male
Muscarinic Antagonists
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
Plant Extracts - pharmacology
Plant Leaves - chemistry
Potassium - pharmacology
Research Papers
Sesamum - chemistry
Sesamum radiatum
contractile activity
acetylcholine
Taenia caeci
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Summary:This study was carried to examine the effects of the aqueous leaf extract of Sesamum radiatum, a laxative plant on the contractile activity of Taenia caeci, an intestinal smooth muscle. Strips of Taenia caeci were rapidly removed from guinea-pig and were suspended between two L-shaped stainless steel hooks in a 10 ml organ bath with Mac Ewen solution. The isometric contractile force of the Taenia caeci strips were recorded by using a strain gauge. S. radiatum aqueous leaf extract (ESera) is a spasmogenic substance. This myostimulant effect is characterized by the increase of the rhythm and the amplitude of isolated guinea-pig Taenia caeci smooth muscle in normal solution and by the development of contracture in modified solution and in solution without calcium. A similar effect was observed with ACh which caused a graded increase of the contractile activity of Taenia caeci. The effects induced by ESera and ACh were reversed in the presence of atropine. The spasmogenic effect induced by ESera could justify partially the use of S. radiatum as laxative in traditional medicine.
ISSN:2505-0044
0189-6016
DOI:10.4314/ajtcam.v8i4.6