Serum leptin and corticosterone levels after exposure to noise stress in rats

• Published in: The Malaysian journal of medical sciences Vol. 12; no. 1; pp. 51 - 56
• Main Authors: Chandralekha, G, Jeganathan, R, Viswanathan, Charan, J C
• Format: Journal Article
• Language: English
• Published: Malaysia Penerbit Universiti Sains Malaysia 01.01.2005
• Subjects: Original; Wistar rats; corticosterone; noise stress; Leptin
• ISSN: 1394-195X; 2180-4303

Even though extensive studies have been conducted on the effect of noise exposure on hearing apparatus / auditory system, information on the effect of noise on the other body functions is sparse. The present study examined the effect of exposure of albino rats to acute and chronic noise stress on two important interlaced endocrine levels. In acute experiments the animals were exposed to 120 dB noise for a duration of 1, 2, 3 hrs. In chronic experiments the animals were exposed to noise for one hour daily for 30, 60 and 90 days. Plasma corticosterone and leptin levels were measured in these animals. There was significant elevation in the levels of corticosterone and leptin after exposure to noise stress. The elevation in corticosterone level after noise stress is in agreement with earlier reports. So noise acts like a stressor and elevates the secretion of the corticosterone, the stress hormone and leptin, the product of the ob gene there is an elevation in leptin levels after noise stress.