Cystic lymphangioma of adrenal gland: a clinicopathological study of 3 cases and review of literature

• Published in: International journal of clinical and experimental pathology Vol. 7; no. 8; pp. 5051 - 5056
• Main Authors: Zhao, Ming, Gu, Qianfeng, Li, Changshui, Yu, Jingjing, Qi, Honggang
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2014
• Subjects: Adrenal Gland Neoplasms - pathology; Adult; Aged; Biomarkers, Tumor - analysis; Diagnosis, Differential; Humans; Immunohistochemistry; Lymphangioma, Cystic - pathology; Male; Original; adrenal cyst; differential diagnosis; Adrenal gland; lymphangioma; D2-40; cystic neoplasm
• ISSN: 1936-2625

Cystic lymphangioma of the adrenal gland is a rare and benign lesion, most often found incidentally during abdominal imaging studies, abdominal surgery or at autopsy. We aimed to retrospectively review all adrenal lymphangioma cases at our hospital, further document their lymphatic origin by immunohistochemical staining and discuss the differential diagnosis with other cystic adrenal gland lesions. A total of 3 adrenal lymphangioma cases were identified. All three patients were men and adults at time of diagnosis aged 41 years, 43 years, and 66 years, respectively. All were incidentally identified during investigating for unrelated reasons, two of which were discovered by routine radiologic check-up while the last one was found during imaging detection of ureteral cancer. The average size of an adrenal lymphangioma lesion was 3.2 cm (range, 2.5-4.6 cm). Histologically, all three cases showed a typical multicystic architecture with dilated spaces lined by flattened, bland, simple lining. The cystic spaces occasionally contained proteinaceous material but lacked red blood cell content. On immunohistochemical stains, D2-40 cytoplasmic staining was positive in all three lesions, whereas AE1/AE3 was negative, thus, confirming their lymphatic nature.