The physical and genetic map surrounding the Lyst gene on mouse Chromosome 13

• Published in: Genomics (San Diego, Calif.) Vol. 40; no. 1; pp. 147 - 150
• Main Authors: MISUMI, D. J, NAGLE, D. L, CARLSON, G. A, MOORE, K. J, MCGRAIL, S. H, DUSSAULT, B. J, SMUTKO, J. S, CHEN, H, CHARLAT, O, DUYK, G. M, EBELING, C, BALDINI, L
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier 15.02.1997
• Subjects: Animals; Base Sequence; Biological and medical sciences; Chromosome Mapping; Chromosomes, Human, Pair 1; Complex syndromes; DNA, Complementary; Female; Humans; Male; Medical genetics; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Proteins - genetics; Vesicular Transport Proteins; Genetic mapping; Human; Immunopathology; Animal model; Skin disease; Nucleotide sequence; Interspecific comparison; Rodentia; Homology; Hemopathy; Chediak syndrome; Immune deficiency; Genetic disease; Eye disease; Vertebrata; Mammalia; Contig; Complementary DNA; Gene; Mouse; Chromosome 13; Molecular biology; Leukocyte disease; Physical map
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1996.4549

During the recent cloning of the mouse Lyst gene we developed both a high-resolution genetic map and a complete YAC and BAC contig of the Lyst critical region on mouse Chromosome 13. We also report the mapping of the human homologue of the mouse Lyst gene (LYST) to 1q43. These data are consistent with LYST being the gene for the human Chediak-Higashi Syndrome and strengthen the synteny relationship between MMU13 and human 1q43.