T cell-macrophage interactions in the immune response to herpes simplex virus: the significance of interferon-γ

• Published in: Journal of general virology Vol. 67; no. 12; pp. 2799 - 2802
• Main Authors: SEID, J. M, LIBERTO, M, BONINA, L, LEUNG, K.-N, NASH, A. A
• Format: Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01.12.1986
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Animals; Biological and medical sciences; Cells, Cultured; Clone Cells; Cytotoxicity, Immunologic; Fundamental and applied biological sciences. Psychology; Fundamental immunology; herpes simplex virus; Immunobiology; Interferon-gamma - biosynthesis; Interferon-gamma - immunology; Interleukin-2 - biosynthesis; Interleukin-2 - immunology; Interleukin-3 - biosynthesis; Interleukin-3 - immunology; Macrophage Activation; Macrophages - immunology; Macrophages - microbiology; Mice; Miscellaneous; Regulatory factors and their cellular receptors; Simplexvirus - growth & development; Simplexvirus - immunology; T-Lymphocytes, Helper-Inducer - immunology; Virus; α-Herpesvirinae; Immunoprotection; Herpesvirus hominis 1; Cell-cell interaction; Herpesviridae; T»-Lymphocyte; Gamma interferon; Macrophage
• ISSN: 0022-1317; 1465-2099
• DOI: 10.1099/0022-1317-67-12-2799

The antiviral properties of a herpex simplex virus type 1-specific 'helper' T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-gamma upon stimulation with the virus in vitro. Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages in vitro and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-gamma in the clone supernatant. The implications of these results for protection against this virus in vivo are discussed.