Correlation between VEGFR2 rs2071559 polymorphism and glioma risk among Chinese population

We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population. Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questio...

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Bibliographic Details
Published inInternational journal of clinical and experimental medicine Vol. 8; no. 9; pp. 16724 - 16728
Main Authors Xu, Guo-Zheng, Liu, Ying, Zhang, Yi, Yu, Jing, Diao, Bo
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2015
Subjects
Original
polymorphism
vascular endothelial growth factor 2 (VEGFR2)
genetics
Glioma
gene
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Summary:We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population. Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping. C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018). CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified.
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ISSN:1940-5901
1940-5901