Cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety

The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic...

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Bibliographic Details
Published inIranian journal of pharmaceutical research : IJPR Vol. 10; no. 3; pp. 497 - 503
Main Authors Miri, Ramin, Javidnia, Katayoun, Amirghofran, Zahra, Salimi, Seyyed Hossein, Sabetghadam, Zahra, Meili, Savis, Mehdipour, Ahmad Reza
Format Journal Article
LanguageEnglish
Published Iran Shaheed Beheshti University of Medical Sciences 2011
Subjects
Original
Cytotoxicity
MTT assay
Nitroimidazole
1,4-Dihydropyridines
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Summary:The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca(2+) channels.
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ISSN:1735-0328
1726-6890