Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of Colorectal Cancer

• Published in: Iranian journal of pharmaceutical research : IJPR Vol. 19; no. 4; pp. 330 - 342
• Main Authors: Mousavi Jam, Sayyid Ali, Morshedi, Mohammad, Yari Khosroushahi, Ahmad, Eftekharsadat, Amir Taher, Alipour, Maedeh, Alipour, Beitullah
• Format: Journal Article
• Language: English
• Published: Iran Shaheed Beheshti University of Medical Sciences 01.01.2020
• Subjects: Original; Cell proliferation; Probiotics; Tumor-suppressive; Colorectal cancer; Apoptosis; Lactobacillus
• ISSN: 1735-0328; 1726-6890
• DOI: 10.22037/ijpr.2019.112135.13547

The paper in hand seeks to evaluate the tumor-suppressive and apoptotic effects of X12 in 1, 2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. The rats were divided into three groups (n = 8-12 per group X12 was administrated to these animals for forty weeks. The findings of this study indicated that X12 administration prevented severe weight loss in DMH-treated rats. It was also determined that X12 administration could prevent the neoplasia incidence, cell proliferation and it also could suppress the tumors' growth. Additionally, a significant improvement was observed in apoptosis indexes and cell proliferation in probiotic-treated rats. In conclusion, this study provides insights into the therapeutic potential of X12 with emphasis on the issue that modulation of apoptosis pathway could leave beneficial effects in the prevention and suppression of colorectal cancer (CRC). However, further studies are in support to clarify the mechanisms involved in the tumor-suppressive effect of probiotics.