Pathologic evaluation of fresh tissue from neurosurgical biopsies: technical and interpretational aspects

A number of rapid techniques are available for intraoperative consultations on neurosurgical biopsies. The press preparation, introduced in this report, is a less traumatizing variation of smash/smear/crush techniques for fresh tissue. It can be prepared in less than 5 min. The purpose of the presen...

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Bibliographic Details
Published inIsrael journal of medical sciences Vol. 32; no. 12; p. 1252
Main Author Kristt, D A
Format Journal Article
LanguageEnglish
Published Israel 01.12.1996
Subjects
Astrocytoma - pathology
Biopsy - methods
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - surgery
Diagnosis, Differential
Humans
Intraoperative Care
Neurosurgery
Pathology, Clinical
Reproducibility of Results
Time Factors
Tissue Fixation
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Summary:A number of rapid techniques are available for intraoperative consultations on neurosurgical biopsies. The press preparation, introduced in this report, is a less traumatizing variation of smash/smear/crush techniques for fresh tissue. It can be prepared in less than 5 min. The purpose of the present report is to describe the technique and its key applications. An additional goal of this study was to identify novel differential diagnostic possibilities that may arise in these preparations. It was found that press preparations clearly maintain the tissues' cytologic features, while key histologic components are preserved in larger fragments. To exemplify the findings using this approach, the features of astrocytomas are described. It is concluded that the press preparation is a rapid and informative means to facilitate pathologic evaluation of fresh tissue from neurosurgical biopsies.
ISSN:0021-2180