Aureonitols A and B, Two New C13‐Polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza

Two new C13‐polyketides, aureonitols A and B (1 and 2), along with five known compounds (3–7), were isolated from the solid fermentation culture of the plant endophytic fungus Chaetomium globosum from the aerial parts of Salvia miltiorrhiza. The structures and absolute configurations of 1 and 2 were...

Full description

Saved in:
Bibliographic Details
Published inChemistry & biodiversity Vol. 16; no. 9
Main Authors Yang, Sheng‐Xiang, Zhao, Wen‐Ting, Chen, Heng‐Ye, Zhang, Lei, Liu, Ting‐Kai, Chen, He‐Ping, Yang, Jian, Yang, Xiao‐Long
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.09.2019
Subjects
antimicrobial activities
Antimicrobial agents
Chaetomium globosum
Ciprofloxacin
Data analysis
Endophytes
Fermentation
Fungi
Ketoconazole
Minimum inhibitory concentration
Polyketides
Salvia miltiorrhiza
Online AccessGet full text

Cover

More Information
Summary:Two new C13‐polyketides, aureonitols A and B (1 and 2), along with five known compounds (3–7), were isolated from the solid fermentation culture of the plant endophytic fungus Chaetomium globosum from the aerial parts of Salvia miltiorrhiza. The structures and absolute configurations of 1 and 2 were determined by comprehensive spectroscopic data analysis and computed methods. Compound 5 was found to display the remarkable antimicrobial activities against four multidrug‐resistant bacteria (Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, and Staphylococcus epidermidis) with MIC values of 3.13–6.25 μg/mL (ciprofloxacin: 0.78–1.56 μg/mL), and also against all tested fungal strains with MIC values of 3.13–25 μg/mL (ketoconazole: 0.78–12.50 μg/mL).
Bibliography:These authors contributed equally to this work.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201900364